The focus of this book is on the plague and epidemic in the history of Qin and Han Dynasties. It not only studies the historical reasons, historical characteristics, epidemic areas and host animals of the natural epidemic diseases that caused these plagues and epidemics, but also the plague influences. In the history of Qin and Han Dynasties, the study of the Qin and Han plagues has had a major and profound impact on the Chinese civilization in the Qin and Han Dynasties and later generations. It can be said that this is a history of alternative civilization that tells about the prosperity and destruction caused by the plague. Understanding the history of the plague will not only help to understand Chinese history more stereoscopically, but also greatly help modern people to prevent plague and eliminate plague.