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Clinical & internal medicineOctober 2011Novel Immunologic Adjuvants
by Rino Rappuoli, Ennio De Gregorio
There is an increasing need of novel adjuvants for preventive vaccines targeting infectious diseases for which conventional formulations have failed. New adjuvants are also needed to improve existing vaccines in the elderly, infants and chronically infected individuals that mount a suboptimal immune response. In addition, adjuvants could be very useful for the development of effective therapeutic vaccines against chronic infections and cancer. In this context, the book provides an overview of vaccine adjuvants with a special focus on their composition and mechanism of action.
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October 2021Footballitics
A tour around the world through the stories of the most politically peculiar football clubs
by Ramon Usall
Can a football match trigger a war? Can football serve the cause of democracy against a dictatorship and vice versa? Footballitics shows us that there is no relevant contemporary historical episode that is not reflected in the trajectory of some football club. Through its stories it is possible to relive most of the events that have marked the last century: anti-colonial rebellions and the class struggle, Nazism and communism, national conflicts and the fight against dictatorships… Footballitics is full of anecdotes and facts which, with the dizzying pace of the greatest matches, tell us the story of these extraordinary political actors that are football clubs and invite us to reflect on their often crucial role as symbols of ideologies, ethnic groups, oppressed communities or rebellious minorities.
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MedicineMarch 2015Ranking Vaccines
Applications of a Prioritization Software Tool: Phase III: Use Case Studies and Data Framework
by Guruprasad Madhavan, Charles Phelps, Rino Rappuoli, Rose Marie Martinez, and Lonnie King, Editors; Committee on Identifying and Prioritizing New Preventive Vaccines for Development, Phase III; Board on Population Health and Public Health Practice; Board on Global Health; Institute of Medicine; National Research Council
SMART Vaccines - Strategic Multi-Attribute Ranking Tool for Vaccines - is a prioritization software tool developed by the Institute of Medicine that utilizes decision science and modeling to help inform choices among candidates for new vaccine development. A blueprint for this computer-based guide was presented in the 2012 report Ranking Vaccines: A Prioritization Framework: Phase I. The 2013 Phase II report refined a beta version of the model developed in the Phase I report. Ranking Vaccines: Applications of a Prioritization Software Tool: Phase III: Use Case Studies and Data Framework extends this project by demonstrating the practical applications of SMART Vaccines through use case scenarios in partnership with the Public Health Agency of Canada, New York State Department of Health, and the Serum Institute of India. This report also explores a novel application of SMART Vaccines in determining new vaccine product profiles, and offers practical strategies for data synthesis and estimation to encourage the broader use of the software.
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Public health & preventive medicineOctober 2013
Ranking Vaccines
A Prioritization Software Tool: Phase II: Prototype of a Decision-Support System
by Guruprasad Madhavan, Kinpritma Sangha, Charles Phelps, Dennis Fryback, Rino Rappuoli, Rose Marie Martinez, and Lonnie King, Editors; Committee on Identifying and Prioritizing New Preventive Vaccines for Development, Phase II; Board on Population Health and Public Health Practice; Board on Global Health; Institute of Medicine
SMART Vaccines--Strategic Multi-Attribute Ranking Tool for Vaccines--is a prioritization software tool developed by the Institute of Medicine that utilizes decision science and modeling to help inform choices among candidates for new vaccine development. A blueprint for this computer-based guide was presented in the 2012 report Ranking Vaccines: A Prioritization Framework: Phase I. Ranking Vaccines: A Prioritization Software Tool,Phase II extends the proof-of-concept presented in the Phase I report, which was based on multi-attribute utility theory. This report refines a beta version of the model developed in the Phase I report and presents its next iteration, SMART Vaccines 1.0. Ranking Vaccines: Phase II discusses the methods underlying the development, validation, and evaluation of SMART Vaccines 1.0. It also discusses how SMART Vaccines should--and, just as importantly, should not--be used. The report also offers ideas for future enhancements for SMART Vaccines as well as for ideas for expanded uses and considerations and possibilities for the future.
