• Biochemistry

      Molecular Cloning

      A Laboratory Manual (three-volume set)

      by Michael R. Green, Joseph Sambrook

      Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years. No other manual has been so popular, or so influential. Molecular Cloning, Fourth Edition, by the celebrated founding author Joe Sambrook and new co-author, the distinguished HHMI investigator Michael Green, preserves the highly praised detail and clarity of previous editions and includes specific chapters and protocols commissioned for the book from expert practitioners at Yale, U Mass, Rockefeller University, Texas Tech, Cold Spring Harbor Laboratory, Washington University, and other leading institutions. The theoretical and historical underpinnings of techniques are prominent features of the presentation throughout, information that does much to help trouble-shoot experimental problems. For the fourth edition of this classic work, the content has been entirely recast to include nucleic-acid based methods selected as the most widely used and valuable in molecular and cellular biology laboratories. Core chapters from the third edition have been revised to feature current strategies and approaches to the preparation and cloning of nucleic acids, gene transfer, and expression analysis. They are augmented by 12 new chapters which show how DNA, RNA, and proteins should be prepared, evaluated, and manipulated, and how data generation and analysis can be handled. The new content includes methods for studying interactions between cellular components, such as microarrays, next-generation sequencing technologies, RNA interference, and epigenetic analysis using DNA methylation techniques and chromatin immunoprecipitation. To make sense of the wealth of data produced by these techniques, a bioinformatics chapter describes the use of analytical tools for comparing sequences of genes and proteins and identifying common expression patterns among sets of genes. Building on thirty years of trust, reliability, and authority, the fourth edition of Molecular Cloning is the new gold standard—the one indispensable molecular biology laboratory manual and reference source.

    • Fiction

      Changing

      by Geoffrey John Jacobs

      As science, micro bio-engineering and humans develop there comes a time when the three become one. That time is now in this present day story. Mankind has evolved, yes, but in many ways he is as pre-occupied with destruction as he is in creating. Intelligent computers and cyborgs, once purely fictional, are now a rapidly developing reality. Changing takes this fact to a whole new frightening level. Anton, an investigative reporter accidentally comes across the realisation that cyborgs are very advanced and are progressively taking over world power. This story takes you on his amazing journey.

    • Fiction
      November 2011

      Code Blood

      by Kurt Kamm

      Colt Lewis, a rookie fire paramedic, is obsessed with finding the severed foot of his first victim after she dies in his arms. His search takes him into the connected lives of a graduate research student, with the rarest blood in the world and the vampire fetishist who is stalking her. Within the corridors of high-stakes medical research laboratories, the shadow world of body parts dealers, and the underground Goth clubs of Los Angeles, Lewis uncovers a tangled maze of needles, drugs and maniacal ritual, all of which lead to death. But whose death? An unusual and fast-paced LA Noir thriller.

    • Biochemistry
      September 2012

      Bacteriophages in Health and Disease

      by Edited by Paul Hyman, Stephen T Abedon.

      Bacteriophages are viruses that infect bacteria. As such, they have many potential uses for promoting health and combating disease. This book covers the many facets of phage-bacterial-human interaction in three sections: the role and impact of phages on natural bacterial communities, the potential to develop phage-based therapeutics and other aspects in which phages can be used to combat disease, including bacterial detection, bacterial epidemiology, the tracing of fecal contamination of water and decontamination of foods.

    • Biochemistry
      August 2012

      Antimicrobial Drug Discovery

      Emerging Strategies

      by Edited by George Tegos, Eleftherios Mylonakis.

      Drug resistance is increasing among a variety of human pathogenic microorganisms such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as one of the most important clinical challenges of this century. Increased general awareness and fear of these pathogens means there is a growing demand for research to tackle the threat of multidrug resistance. Documenting the latest research in the field, this book discusses current and promising activities to discover new antimicrobials in five key areas: molecular genetics and systems microbiology; synthetic, computational chemistry and chemoinformatics; High Throughput Screening (HTS); non-vertebrate model hosts; and light- and nano-based technologies.

    • Science & Mathematics
      December 1996

      Concise Encyclopedia Biochemistry and Molecular Biology

      by Thomas A. Scott, E. Ian Mercer

      "In summary, this encyclopedia is a quick and up-to-date reference covering most of the terms used in the very fast growing fields of biochemistry and molecular biology. It is recommended to students and researchers in biology."Jörg Schwender in: Journal of Plant Physiology 1-2 1998

    • Science & Mathematics
      July 2017

      Anwendungen

      by Michael Quednau

      Von chemischen und mikrobiologischen Grundlagen bis zu Anwendungen im Bergbau und der industriellen Synthese von Nanopartikeln fasst dieses zweibändige Lehrbuch zum ersten Mal die Gesamtheit der Geomikrobiologie für den Studenten zusammen. Dieser zweite Teil befasst sich mit Methoden für industrielle Anwendungen, Urban Mining, der Skalierung, sowie speziellen Anwendungen.

    • Science & Mathematics
      May 2018

      Riedel Moderne Anorganische Chemie

      by Christoph Janiak, Hans-Jürgen Meyer, Dietrich Gudat, Philipp Kurz, Erwin Riedel, Hans-Jürgen Meyer

      Dieses Standardwerk der Modernen Anorganischen Chemie vermittelt fundiertes Wissen der wesentlichen Teilgebiete der anorganischen Chemie. Die Überarbeitung zur vorliegenden 5. Auflage basiert auf aktuellen Forschungergebnissen sowie Vorlesungsinhalten der Autoren. Besonders das Kapitel zur Bioanorganik wurde umfassend verbessert und ergänzt.

    • Science & Mathematics
      May 2018

      Environmental Toxicology

      by Luis M. Botana, Natalia Vilarino, Ines Rodríguez, Amparo Alfonso, Carmen Alfonso, Alvaro Antelo, M. Carmen Louzao, Paula Abal, Carmen Vale González, Andrea Boente Juncal, Aida González Méndez, Eva Alonso, Rebeca Alvarino, Eva Cagide, Mercedes Álvarez, Maria J. Sainz, Jesús M. González-Jartín, Olga Aguín, J. Pedro Mansilla, Ana M. Botana

      Organic and inorganic chemicals frequently exhibit toxic, mutagenic, carcinogenic, or sensitizing properties when getting in contact with the environment. This comprehensive introduction discusses risk assessment and analysis, environmental fate, transport, and breakdown pathways of chemicals, as well as methods for prevention and procedures for decontamination.

    • Science & Mathematics
      November 2018

      Organic Chemistry of Biomolecules

      by Dennis Löwik, Thomas Boltje

      Organic Chemistry of Biomolecules provides an introduction to the field from a synthetic chemistry point of view. Covering carbohydrates, peptides, amino acids and nucleic acids, the authors explain how to plan and implement the synthesis of these molecules in the most efficient manner and give an overview of analytical aspects. Written in a simple, lucid language, the book is an excellent tool for graduate students and synthetic chemists.

    • Science & Mathematics
      May 2018

      Microbial Energy Conversion

      by Zhenhong Yuan

      The book provides an overview on various microorganisms and their industrialization in energy conversion, such as ethanol fermentation, butanol fermentation, biogas fermentation and fossil energy conversion. It also covers microbial oil production, hydrogen production and electricity generation. The content is up to date and suits well for both researchers and industrial audiences.

    • Science & Mathematics
      January 2019

      Bioorganometallic Chemistry

      by Wolfgang Weigand, Ulf-Peter Apfel

      Bioorganometallic Chemistry is an excellent introduction to this transdisciplinary field which is straddled with biochemistry, medicine and organometallic chemistry. The book is a comprehensive review on the latest advances of this rapidly growing area, as well as historical background and future trends, revealing a tremendous potential of bioorganometallic compounds as novel drug candidates and diagnostic tools.

    • Medicine
      May 1988

      Vitamins

      by Wilhelm Friedrich

    • Science & Mathematics
      September 2018

      Protein Tyrosine Phosphatases

      Structure, Signaling and Drug Discovery

      by Lalima G. Ahuja

      Cellular signaling forms the basis of physiological well-being of the cell. Reversible protein phosphorylation is one of the key mechanisms employed for cell signaling. Tyrosine residues when phosphorylated by specific signaling enzymes called the Protein Tyrosine Kinases (PTK) serve as the 'signaling currency' of the cell. To ensure that this currency is wisely, Protein Tyrosine Phosphatases (PTP) regulate their required amounts in the cell. The PTPs hence ensure a signaling-balance and homeostasis critical to cell survival and growth. The role of PTPs is well established in neuronal development, growth and differentiation, glucose homeostasis, immune response and also platelet signaling. PTPs are increasingly finding their position at the frontiers of drug discovery. This book will aim to describe all these advances in the field of PTP structure and signaling. The book will serve as an essential reference for anyone working on protein phosphorylation, signaling and drug discovery.

    • Science & Mathematics
      November 2018

      Industrial Biotechnology

      by Mark Anthony Benvenuto

      The book provides an excellent introduction to industrial biotechnology, addressing the applications of biomolecules and living systems in industrial manufacturing of various products. Each part of the book is devoted to a certain biotech sector, such as biofuels, food, chemicals, pharmaceuticals and materials. The book also covers the environmental aspects of industrial biotechnology and the principles of bio-based economy.

    • Science & Mathematics
      September 2018

      Phosphorus Chemistry

      The Role of Phosphorus in Prebiotic Chemistry

      by Yufen Zhao, Yan Liu, Xiang Gao, Pengxiang Xu, Xiamen University Press

      The book is the first thorough study of the role of phosphorus chemistry in the origin of life. This book starts with depiction of the phosphorus role in life creation and evolution. Then it outlines in vital processes how different phosphorus-containing compounds participate as biomarker in life evolution. Written by renowned scientists, it is suitable for researchers and students in organic phosphorus chemistry, biochemistry and etc.

    • Business, Economics & Law
      November 2018

      Bioinorganic Chemistry

      by Daniel Rabinovich

      Bioinorganic Chemistry bings together Biochemistry and Inorganic Chemistry, but also lies at the interface with Chemistry, Biology, and Physics. Advanced chemical and biochemical aspects and methods are thoroughly discussed in Bioinorganic Chemistry. The book provides students and researchers with a general overview of the many very fundamental tasks performed by inorganic elements in living organisms as well as the related methods and theories with particular emphasis on enzymatic conversions and electron transfer. This goes along with the elucidation of model systems and technical applications of both, concepts learned from nature as well as biological systems. Readers gain an understanding of the concepts of coordination chemistry in biological environments, and to utilize this knowledge to analyze the influence of such an environment on the reactivity of a metal centre. This expertise should serve as a tool for development of e.g. metalloenzyme applications, material synthesis and pharmaceutical development.

    • Science & Mathematics
      April 2018

      Organophosphorus Chemistry

      Novel Developments

      by György Keglevich, Péter Ábrányi-Balogh, Péter Bagi, Erika Bálint, Bubun Banerjee, Goutam Brahmachari, Imre G. Czismadia, Alajos Grün, Réka Henyecz, Réka Herbay, Péter Huszthy, Károly Kánai, Nóra Zs. Kiss, Tamara Kóvacs, Mátyás Milen, Zoltán Mucsi, Dávid Illés Nagy, Zita Rádai, Tamás Szabó, Hajnalka Szabó-Szentjóbi, Ádám Tajti, Tünde Tóth, Anna Tripolszky

      Organophosphorus Chemistry presents a groundbreaking resource in this branch of organic chemistry that demonstrates how phosphorus-containing compounds can be manipulated in a variety of organic reactions. The authors give an overview of the newest trends and synthesis strategies, introduce bioactive and environmentally friendly organophosphorus compounds and show their importance in mainstream organic chemistry.

    • Biochemistry
      February 2019

      The Receptor RAGE in Vascular and Cerebral Dysfunctions

      by Editor(s): Jean-Luc Wautier

      After chemistry, the origins of biochemistry began at the end of the 19th century. The first major step was made when glycated hemoglobin, HbA1c, was found to be a precious index to follow an adapted antidiabetic treatment.This discovery led to the identification of cell receptors, present in vascular cells, leukocytes, neuronal cells. One such cell receptor, RAGE, has been shown to be a major contributor in cell alteration, the development of vascular complications in diabetes mellitus, ageing, and Alzheimer’s disease.This book shows that the axis AGE-RAGE and the activation of RAGE by other ligands open up a possible new therapeutic approach to prevent complications of diabetes mellitus and ageing. As such, it will particularly appeal to chemists, biochemists, biologists, immunologists, nutritionists, doctors, cardiologists, and neurologists.

    • Biochemistry
      July 2018

      Plant Bioactive Molecules

      by Author(s): Massimo Maffei

      Plants have always been a source of nourishment and healing for living things. Their dual task of producing nutrients and medicines has played a key role in the evolution of herbivore and omnivore organisms. The so-called secondary metabolites are molecules with well-defined functional roles. These compounds are produced to defend plants from abiotic and biotic stresses. The complexity of the molecular structures produced by plants is only equal to their versatility and chemical diversity, while the harmonic intertwining of biosynthetic and metabolic pathways offers a perfect picture of the adaptive plasticity of plants to changing environmental conditions.This book is divided into three parts designed to provide the reader with a general overview, a biochemical and a biotechnological approach to plant bioactive molecules.The first part analyses the concepts of chemical diversity, sustainability and functional role of bioactive molecules, by exploring the sites of synthesis and accumulation, the plant defence strategies and the use of bioactive molecules as food supplements and as a source for natural products to fight diseases. The first part ends with the study of chemotaxonomy.The second part is dedicated to plant biochemistry, with the detailed description of the main biosynthetic pathways leading to the synthesis of phenols and flavonoids, terpenes, oxylipins and nitrogen-containing substances.The third and final part describes plant biotechnology and production of bioactive molecules with industrial processes, both in vivo and in vitro. Special attention is paid to cell and tissue cultures, roots and shoots cultures, technological aspects describing bioreactors, biofermenters and photobioreactors. The book concludes with a chapter describing the genetic engineering strategies for the production of plant bioactive molecules, facing with ethical problems, risks and benefits of using recombinant DNA in genetically modified organisms (GMOs) and the use of molecular pharming, with a general discussion on food safety.

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