• Radiotherapy

      CT Anatomy for Radiotherapy

      by Pete Bridge

      Knowledge of CT anatomy is increasingly vital in daily radiotherapy practice, especially with more widespread use of cross-sectional image-guided radiotherapy (IGRT) techniques. Existing CT anatomy texts are predominantly written for the diagnostic practitioner and do not always address the radiotherapy issues while emphasising structures that are not common to radiotherapy practice. CT Anatomy for Radiotherapy is a new radiotherapy-specific text that is intended to prepare the reader for CT interpretation for both IGRT and treatment planning. It is suitable for undergraduate students, qualified therapy radiographers, dosimetrists and may be of interest to oncologists and registrars engaged in treatment planning. All essential structures relevant to radiotherapy are described and depicted on 3D images generated from radiotherapy planning systems. System-based labelled CT images taken in relevant imaging planes and patient positions build up understanding of relational anatomy and CT interpretation. Images are accompanied by comprehensive commentary to aid with interpretation. This simplified approach is used to empower the reader to rapidly gain image interpretation skills. The book pays special attention to lymph node identification as well as featuring a unique section on Head and Neck Deep Spaces to help understanding of common pathways of tumour spread. Fully labelled CT images using radiotherapy-specific views and positioning are complemented where relevant by MR and fusion images. A brief introduction to image interpretation using IGRT devices is also covered. The focus of the book is on radiotherapy and some images of common tumour pathologies are utilised to illustrate some relevant abnormal anatomy. Short self-test questions help to keep the reader engaged throughout.

    • Diseases & disorders
      January 2012

      Fast Facts: Eating Disorders

      by Hans Steiner, Martine F Flament

      The earlier a person with an eating disorder is treated, the greater the likelihood of physical and psychological recovery. Fast Facts: Eating Disorders guides the reader through the latest evidence in detection, diagnosis and efficacy of treatments for anorexia, bulimia and related disorders. In this highly readable handbook, the two renowned authors demonstrate how a carefully coordinated and multidisciplinary - intervention can be successful. They address the important role of primary care physicians and other frontline healthcare workers in detecting eating disorders, working with the treatment team and monitoring the patient, and the positive impact these services can have on the rate and level of recovery.

    • Diseases & disorders
      May 2014

      Fast Facts: Obesity

      by David Haslam, Gary Wittert

      “Not to broach the subject of excess weight with a patient is a dereliction of duty as a healthcare professional,” say the authors of Fast Facts: Obesity. “Patients who smoke are rapidly identified for intervention, and the same should be true of anyone who is obese”Every consultation is an opportunity to educate and encourage patients to pursue better health. Fast Facts: Obesity is packed with practical advice on how best to support patients to improve their nutrition and levels of physical activity, and change their habits, with simple and achievable goals tailored to individual needs and concerns. Contents: • Patient assessment • Causes and science • Cardiometabolic consequences • Other consequences • Management: diet • Management: physical activity • Management: behavioral therapy • Pharmacological and surgical treatments • Children, the elderly and pregnant women • Management tools, prevention and advocacy Useful resources

    • Diseases & disorders
      January 2011

      Fast Facts: Benign Prostatic Hyperplasia

      by Roger Kirby, Peter Gilling

      Most men with BPH can be diagnosed and managed in the primary care setting. In choosing appropriate treatment, clinicians must take into account not only the nature and severity of symptoms but also the preferences of the patient and his immediate family, cost–benefit considerations and long-term effectiveness of therapy.Written by two leading urologists, Fast Facts: Benign Prostatic Hyperplasia provides a refreshingly readable, practical overview of the pathophysiology, diagnosis and treatment of BPH including:- Use of DRE and PSA results to discriminate between prostate cancer and BPH- An evidence-based review of the latest medical therapies- A concise overview of the surgical and minimally invasive treatment options- When to refer to a urologistThere is important work to do to raise awareness of men’s health issues in general and the problem of BPH in particular. Lower urinary tract symptoms are among the commonest reasons for a man to consult his doctor, and this ever-popular book – the first 7th edition in the Fast Facts series – remains a must-read for all primary care providers. Table of Contents: Pathophysiology Diagnosis Medical management Traditional surgical treatment options Minimally invasive treatment options Considerations in treatment decisions Issues in BPH

    • Medicine
      January 2016

      Clinical Care of the Diabetic Foot, 3rd Edition

      by David G. Armstrong, DPM, MD, PhD, and Lawrence A. Lavery, DPM, MPH, Editors

      The third edition of Clinical Care of the Diabetic Foot has been fully revised and updated, and continues to be the essential handbook on foot care and the treatment of the diabetic foot.The diabetic foot is typically the victim of nerve damage, micro- and macrovascular disease, and faulty healing, mechanisms that without proper care can lead to amputation. More than 80,000 diabetes-related amputations are performed in the United States each year, but non-specialist primary care providers, as well as residents, nurses, and diabetes educators, can help prevent this devastating, life-altering, and expensive complication. Healthcare professionals and medical students alike will find that this concise, well-indexed, and updated guide offers practical advice on detecting and managing diabetes-related foot complications.

    • Medicine
      August 2016

      Intensive Diabetes Management

      by Howard A. Wolpert

      Intensive diabetes management is the process by which blood glucose levels are closely controlled using multiple daily insulin injections or an insulin pump. People who use this method of diabetes management must be closely aligned with their health care team and highly motivated because it not only requires close scrutiny of blood glucose levels, but also constant monitoring of food intake and medication dosage, among other things.Although difficult to maintain, intensive diabetes management has proven very effective and is now the rule, rather than the exception, in diabetes care. Virtually all patients with diabetes—type 1 or type 2—can improve their glycemic control and overall health through intensive diabetes management.Intensive Diabetes Management is geared toward the health care practitioner who wants to implement this method in his or her patients. It emphasizes a team approach to patient care and offers guidance in helping patients move toward treatment goals appropriate for their individual skills and medical condition.Individual sections address all of the key topics in intensive diabetes management, including rationale/physiological Basis, team approach, education, pyschosocial issues patient selection/goals of therapy, insulin regimens, insulin pump therapy, monitoring, and nutrition management.This new edition is updated to cover the latest advances in medical research. New insights into diabetes and how they impact this particular treatment are covered. In addition, the data, guidelines, and procedures have been revised to reflect that newest positions of the American Diabetes Association's standards of care.

    • Medicine
      August 2018

      Therapie chronisch entzündlicher Darmerkrankungen

      by Torsten Kucharzik, Emile Rijcken, Dominik Bettenworth, Norbert Senninger

      In diesem Buch stellen führende Internisten und Chirurgen die Therapie chronisch entzündlichen Darmerkrankungen wie Morbus Crohn und Colitis ulcerosa umfassend und handlungsorientiert dar. Sie beschreiben die jeweils spezifischen Aspekte der Behandlung, aber insbesondere auch die Schnittstellen der interdisziplinären Zusammenarbeit, die eine enge Abstimmung zwischen Internisten und Chirurgen erfordert. Die primäre, medikamentöse Therapie wird dem operativen, möglichst darmerhaltenden Vorgehen gegenüber gestellt. Diagnostik, Sondersituationen (z.B. Pouchitis), extraintestinalen Manifestationen und therapieassoziierten Komplikationen sind eigene Kapitel gewidmet. Abgerundet wird das Buch durch Pathogenese und Epidemiologie, Besonderheiten der CED in unterschiedlichen Lebensabschnitten sowie Begleittherapien.

    • Infectious & contagious diseases
      October 2011

      Human Papillomavirus Vaccines

      by Eduardo L Franco

      This book outlines the pathobiology and immunology of human papillomavirus, clinical data, and safety and tolerance issues. Public health and clinical guidelines are also explored. The authors are among the most knowledgeable clinical and basic scientists in the fields of HPV immunology and pathogenesis, epidemiology and infectious diseases.

    • Infectious & contagious diseases
      October 2011

      Primary Care Management of Community-Acquired Pneumonia

      by Thomas J Marrie

      This book addresses community-acquired pneumonia – the most common cause of death due to infection in industrialized nations and the most common cause of death in low-income countries. Although it can occur at any age, it primarily affects the young and elderly. The book covers the whole breadth of community-acquired pneumonia, from the causes and pathophysiology to diagnosis and treatment of pneumonia in children and adults (both in the outpatient setting and under hospitalization). The book also addresses antimicrobial resistance issues, common complications of pneumonia and the role of influenza and pneumococcal vaccines in preventing pneumonia.

    • Immunology
      March 2012

      Emerging Oral Medications for Multiple Sclerosis

      by Sten Fredrikson, Jan Hillert

      In the past two decades we have experienced a profound change in our view of multiple sclerosis. Nevertheless, we are still only at the beginning of a new era for treatment of the disease. This book, in four sections written by acknowledged experts, first addresses the unmet medical needs associated with available treatments. The second chapter is a thorough exploration of potential pathogenetic mechanisms that could be targeted with new oral medications. In the third chapter, oral immunomodulators in late-stage clinical trials are described, and the final chapter deals with oral therapeutics in the pipeline and future directions for therapeutic approaches, including some symptomatic therapies and hypothetical strategies for promoting CNS protection and repair.

    • Oncology
      December 2011

      mTOR Inhibitors in Cancer Treatment

      by Leonidas C Platanias

      Increased understanding of the mTOR signaling pathway in relation to malignant cells has prompted extensive efforts to develop new therapeutic approaches. The six chapters of this book summarize the current status of efforts using mTOR inhibitors for the treatment of several malignancies. First generation mTOR inhibitors (rapalogues) are now approved by the US FDA for the treatment of renal cancer, and further new drugs may be approved. There is also hope that the second generation of catalytic inhibitors of mTOR that target both TORC1 and TORC2 complexes will be more powerful and effective antineoplastic agents, and clinical trials using such agents are currently ongoing. This book provides a comprehensive review on the emerging roles of mTOR inhibitors in different malignancies in which they have high therapeutic potential.

    • Immunology
      March 2012

      Pneumococcal Conjugate Vaccines

      by Ger T Rijkers

      Streptococcus pneumoniae (the pneumococcus) is a pathogen with significant disease implications, especially for the (very) young and the (very) old. It causes mucosal infections such as otitis media and pneumonia but also causes invasive diseases such as bacteremia and meningitis. In this book of seven chapters, international experts address the major challenges facing the current use and future development of pneumococcal conjugate vaccines – both from the scientific and the political standpoint. As such, the book comprises a comprehensive and up-to-date overview of this rapidly evolving field.

    • Immunology
      November 2011

      Plant-derived Vaccines: Technologies & Applications

      by Franco M Buonaguro

      This book includes 11 chapters spanning most of the issues involved in plant-based vaccine production, including intellectual property considerations and veterinary applications. In addition to the detailed description of antigen expression in different plant systems, adjuvant production and plant glycosylation of proteins are also analyzed.

    • Oncology
      September 2012

      Molecular-Based Decision Making for Personalized Cancer Management

      by Rafael Rosell

      The main goals of this book are to offer a straightforward guide to the wealth of information on cancer genetics currently available in basic scientific journals, and to illustrate the multiple opportunities for application of this knowledge to daily clinical practice. Dr Rosell has convened a team of international experts to highlight the clinical relevance of molecular genetics and signaling pathways in disease and how this understanding can drive informed clinical decision making. There are seven chapters in the book, beginning with gastrointestinal stromal tumors and moving through melanoma, ovarian cancer, triple negative breast cancer, gastric cancer, lung adenocarcinoma and mesothelioma.

    • Oncology
      April 2013

      Monoclonal Antibodies in Oncology

      by Fatih M Uckun

      Monoclonal antibodies (mAbs) have been developed to improve the treatment outcome of cancer patients undergoing therapy according to multimodality regimens without a significant increase of treatment-associated toxicity. This five-chapter book provides examples where mAbs that have become part of the standard of care in cancer patients and cancer types that have responded to mAbs. Individual chapters devoted to each target cancer type illustrate the importance of recognizing and leveraging the unique features of the respective mAb in order to fully realize their therapeutic potential.

    • Immunology
      December 2013

      Microbial Drug Resistance

      by Vladimir Krcméry

      We face the prospect of physicians in hospitals trying to treat patients infected by multidrug-resistant organisms that are unresponsive to all available antibiotics. This book of twelve chapters addresses the threats of antibiotic resistance and the potential transition into a postantibiotic era. Internationally renowned experts have provided an extensive overview exploring current and emergent pathogen challenges, measures to prevent antimicrobial resistance and the direction of future research.

    • Immunology
      July 2013

      Personalized Management of Multiple Sclerosis

      by Bianca Weinstock-Guttman, Murali Ramanathan, Robert Zivadinov

      Multiple sclerosis is a highly heterogeneous disease with a dissimilar disease course and a different response to therapies among individual patients. Although a cure for MS is still a distant prospect, the disease will be manageable in most patients with appropriate therapies. The most important challenge regarding these therapeutic interventions will be to tailor the therapy to the needs of the patients and the severity of the disease. This book of thirteen concise chapters provides an expert perspective on the disease and its treatment in different individuals and future prospects and directions for research and therapy.

    • Immunology
      February 2014

      Novel Approaches in Immunoassays

      by Hannu Koistinen, Ulf-Håkan Stenman

      In recent decades, immunoassays have become widely used for the sensitive and specific investigation of a variety of different analytes, from proteins to steroids, drugs and microbes. In the five chapters of this book, immunoassay experts first establish the general principles of immunoassay before highlighting new developments, especially in the area of assay technology. The book illustrates the versatility of immunoassays and emphasizes how one type of assay is not suitable for all applications. The authors place the technology in context and explore pros and cons, recognizing that novel assays are still needed for many purposes (e.g., healthcare, forensics, environmental and food analysis).

    • Oncology
      June 2013

      Monoclonal Antibodies Targeting EGFR/HER2 and Clinical Outcomes in Cancer Treatment

      by Jan B Vermorken

      Monoclonal antibodies (mAbs) have rapidly become one the largest classes of new drugs approved for the treatment of cancer – 14 mAbs have been approved by the US FDA for cancer therapy. This book focuses on mAbs targeting EGFR and HER2 and, in five chapters, summarizes information on the use of these mAbs in colorectal cancer, breast cancer, lung cancer, genitourinary cancers, tumors of the skin, the CNS and the head and neck, and gynecologic malignancies.

    • Infectious & contagious diseases
      January 2014

      Clinical Insights: Influenza Surveillance

      by John Oxford

      Traditional influenza surveillance is often referred to as one of the best developed global surveillance systems. Nevertheless, there are huge gaps in many countries, particularly at the dangerous interface between humans, animals and birds. Effective surveillance helps policy makers prepare for upcoming influenza seasons, develop suitable strains for vaccine production and prepare for the possibility of a pandemic outbreak. In the seven chapters of this book, international epidemiologists, virologists, pandemic resilience managers and clinicians convene to share their expert analysis and commentary on influenza surveillance. The book will be of great interest to epidemiologists, clinicians, respiratory medicine specialists, virologists and medical and biomedical students seeking to gain a greater understanding of the surveillance of an ever-present biological threat.

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