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      • Trusted Partner
        Science & Mathematics
        March 2017

        The Handbook of Microbial Metabolism of Amino Acids

        by J P F D'Mello, K Abe, M I Afzal, M Akhtar, J M P Alves, R Balana Fouce, Q Bashir, R A Bender, Simon Brown, Catherine Cailliez-Grimal, R William Caldwell, Barbara Campanini, Yingying Cao, Trinad Chakraborty, D Charlier, N P Chowdhury, O O Coker, Daniela de Biase, Stephane Delaunay, Renwick C J Dobson, Mike F Dunn, D Fulton, Fabio Giovannercole, D E Holmes, A.O Hudson, Y Kera, G D Kornfeld, F Leroy, Z Liao, Rob D Locy, J S Lott, Patrick M Lucas, R Lucas, P Ludovico, J M Moran, A Mozzarelli, A J Nieuwkoop, N Osorio, John V Paietta, Prasit Palittapongarnpim, Emily J Parker, A Parthasarathy, F G Pearce, Eugenia Pennacchietti, Y Perez-Pertejo, R S Phillips, N Rashid, P J Quinn, F Rodrigues, M J Romero, B Sampaio-Marques, M A Savka, K Shibata, David C Simcock, H V Simpson, J A Smith, S Takahashi, Saleh Umair, X Wang, Matthew J Wargo, S Watanabe, Freya Wencker, W Ziebuhr, I W Dawes

        This book collates and reviews recent advances in the microbial metabolism of amino acids, emphasizing diversity - in terms of the range of organisms under investigation and their natural ecology - and the unique features of amino acid metabolism in bacteria, yeasts, fungi, protozoa and nematodes. As well as studying the individual amino acids, including arginine, sulfur amino acids, branched-chain amino acids and aromatic amino acids, a number of themes are explored throughout the work. These include: - Comparative issues between the metabolism of microbes and those of higher organisms, including plants and mammals - Potential for drug targets in pathways of both biosynthesis and degradation of amino acids - Relationship between amino acids or associated enzymes and virulence in parasitic pathogens - Practical implications for food microbiology and pathogen characterization - Future priorities relating to fundamental biochemistry of microrganisms, food quality and safety, human and animal health, plant pathology, drug design and ecology As the volume of research into the metabolism of amino acids grows, this comprehensive study of the subject is a vital tool for researchers in the fields of biological, medical and veterinary sciences, including microbiology, biochemistry, genetics and pathology. This book is also essential for corporate organizations with active research and development programmes, such as those in the pharmaceutical industry. ; This book collates and reviews recent advances in the microbial metabolism of amino acids, emphasizing diversity - in terms of the range of organisms under investigation and their natural ecology - and the unique features of amino acid metabolism in bacteria, yeasts, fungi, protozoa and nematodes. ; -: PrefacePART I: GLUTAMATE1: Structural and Functional Properties of Glutamate Dehydrogenases2: Glutamate Decarboxylase in Bacteria3: The Yeast GABA ShuntPART II: LYSINE, ARGININE AND HYDROXYPROLINE4: Lysine Biosynthesis in Microorganisms5: Arginine Deiminase in Microorganisms6: Arginase and Microbial Pathogenesis in the Lungs7: Arginine and Methionine as Precursors of Polyamines in Trypanosomatids8: Ornithine and Lysine Decarboxylation in Bacteria9: The Role of Nitric Oxide Signalling in Yeast Stress Response and Cell Death10: Hydroxyproline Metabolism in MicroorganismsPART III: SERINE AND THREONINE11: Cellular Responses to Serine in Yeast12: Threonine Degradation in Hyperthermophilic OrganismsPART IV: SULFUR AMINO ACIDS13: Methionine Synthesis in Microbes14: Regulation of Sulfur Amino Acid Metabolism in Fungi15: Insight on O-Acetylserine Sulfhydrylase Structure, Function and Biopharmaceutical ApplicationsPART V: BRANCHED-CHAIN AMINO ACIDS16: Metabolic Engineering of Corynebacterium glutamicum for L-Valine Production17: Flavour Formation From Leucine by Lactic Acid BacteriaPART VI: AROMATIC AMINO ACIDS AND HISTIDINE18: Microbial Degradation of Phenolic Amino Acids19: The Biosynthesis of Tryptophan20: Tryptophan Biosynthesis in Bacteria: Drug Targets and Immunology21: The Kynurenine Pathway of Tryptophan Metabolism in Microorganisms22: Histidine Degradation in Bacteria23: Histidine Phosphatase Superfamily in Pathogenic BacteriaPART VII: D-AMINO ACIDS24: Functions and Metabolism of D-Amino Acids in Microorganisms25: Pathways of Utilization of D-Amino Acids in Higher OrganismsPART VIII: ECOLOGY26: Rhizobial Amino Acid Metabolism: Polyamine Biosynthesis and Functions27: Working Together: Amino Acid Biosynthesis in Endosymbiont-Harbouring Trypanosomatidae28: Amino Acid Metabolism in Helminths29: Microbial Degradation of Amino Acids in Anoxic Environments30: Utilization of N-Methylated Amino Acids by Bacteria31: Biofilm Formation: Amino Acid Biomarkers in Candida albicans32: Recent Advances Underpinning Innovative Strategies for the Future

      • Trusted Partner
        Science & Mathematics
        December 2016

        Natural Polymers for Drug Delivery

        by Harsha Kharkwal, Harsha Kharkwal, Anupama Dhiman, Srinivas Janaswamy, Srinivas Janaswamy, Neerupma Dhiman, Ram Prasad, Monika Joshi, Deepshikha Pande Katare, Kumud Bala, Wong Tin Wui, Anirbandeep Bose, Heather Sheardown, Ly Le, Ali Demir Sezer, Erdal Cevher, K.H. Basavaraj, Zeenat Iqbal, Krutika K Sawant, S G Gattani, Vishal V Pande

        Natural polymers have been utilized extensively in food, pharmaceuticals, cosmetics, textiles, oil drilling and paint industries. Their non-toxic and inexpensive attributes readily enhance their commercial acceptability and make them potent agents in lieu of synthetic polymers. This book explores the opportunistic utility of natural polymers in developing effective drug delivery systems and provides a comprehensive and up-to-date analysis of their source, chemical structure and mechanism of action. Covering novel polymers for drug delivery - in particular extracts from plants, microorganisms and proteins, as well as water soluble and water insoluble biodegradable polymers - it presents an encyclopaedic overview of natural polymers': - quintessential roles in binding drugs towards enhancing bioavailability - modification and derivatization for targeted delivery - role as active drugs Natural Polymers for Drug Delivery is an invaluable resource for researchers, students and industrial scientists in the fields of biochemistry, chemistry, pharmacology and food science. ; This book provides an overview of the source, chemical structure and action mechanism of natural polymers. Focusing on their utility in developing effective drug delivery systems, it covers polymers’ role in binding drugs towards enhancing bioavailability, modification and derivatisation for targeted delivery, and modification as active drugs. ; 1: Natural Polymers for Drug Delivery: An IntroductionSection I: Drug Delivery Based on Different Classes of Polymers2: Cellulose-based Polymeric Systems in Drug Delivery3: Hydrocolloids-based Hydrogels in Drug Delivery4: Water Soluble Biodegradable Polymers for Drug Delivery5: Polysaccharide-based Drug Carriers6: Polymer-based Nanoparticles for Drug Delivery Systems and Cancer Therapeutics7: Polymer Nanocomposite-based Biosensors for Drug Delivery ApplicationsSection II: Polymeric Interaction and Conjugates8: Polymer-Drug Conjugates: Targeted Drug Delivery9: Protein-Drug Conjugates: A New Class of Biotherapeutics10: Microencapsulation for Controlled Gastrointestinal Delivery of Probiotics and PrebioticsSection III: Disease-specific Drug Delivery Systems11: Chitosan in Drug Delivery and Targeting for Cancer Treatment12: Polymers as Biodegradable Matrices in Transdermal Drug Delivery13: Ocular Drug Delivery Systems14: Natural Polymers Targeting Habitual Disease15: Bioengineered Wound and Burn Healing Substitutes: Novel Design for Biomedical and General Applications

      • Biology, life sciences

        From Cells to Organisms

        Re-Envisioning Cell Theory

        by Sherrie L. Lyons

        More than a history, From Cells to Organisms delves into the nature of scientific practice, showing that results are interpreted not only through the lens of a microscope, but also through the lens of particular ideas and prior philosophical convictions. Before the twentieth century, heredity and development were considered complementary aspects of the fundamental problem of generation, but later they became distinct disciplines with the rise of genetics. Focusing on how cell theory shaped investigations of development, this book explores evolution, vitalism, the role of the nucleus, and the concept of biological individuality. Building upon the work of Thomas Huxley, an important early critic of cell theory, and more recent research from biologists such as Daniel Mazia, From Cells to Organisms covers ongoing debates around cell theory and uses case studies to examine the nature of scientific practice, the role of prestige, and the dynamics of theory change.

      • Fiction
        November 2011

        Code Blood

        by Kurt Kamm

        Colt Lewis, a rookie fire paramedic, is obsessed with finding the severed foot of his first victim after she dies in his arms. His search takes him into the connected lives of a graduate research student, with the rarest blood in the world and the vampire fetishist who is stalking her. Within the corridors of high-stakes medical research laboratories, the shadow world of body parts dealers, and the underground Goth clubs of Los Angeles, Lewis uncovers a tangled maze of needles, drugs and maniacal ritual, all of which lead to death. But whose death? An unusual and fast-paced LA Noir thriller.

      • Science & Mathematics
        November 2020

        Plants for Novel Drug Molecules

        Ethnobotany To Ethnopharmacology

        by Bikarma Singh & Yash Pal Sharma

        The present book is based on twenty five excellent scientific contributions of seventy researchers from topmost research organizations. The book begin with plants used in Sowa-Rigpa system of food and medicine, followed by traditional uses of plants as medicine among Khasi tribe living in northeast India. This compilation contains several research techniques highlighting methods and analysis of documented data, and procedure for scientific validation of findings. Methods for assessing traditional knowledge of highly threatened plants such as Hodgsoniaheteroclita, pharmacological applications of family asteraceae, ethnobotany of family apiaceae, plants used in managing leucorrhea, plants as animal care, phytochemistry of Arisaemajacquemontii, Andrographispaniculata, Blumealacera, Boerhaaviadiffusa, Hemidesmusindicus, Pterocarpussantalinus, Rauwolfiaserpentina, Rauwolfiatetraphylla, and several other ethnobotanical and ethnopharmacological parameters used in studying current science is described in this book. Besides, it is followed by several research topics focused to the clinical arena, plants used in relation to cancer, diabetes, skin disorders and many other aspects relates to animal and human health care. Todays food supplements derived from plants are of high demand, and this compilation also highlighted several plants used as nutraceuticals. It has been observed that herbs contain many bioactive compounds with powerful antioxidant properties as evidence from the scientific data, and few research on lianas, lichens and role of allylisothiocyanate as a bioprotective agent also discussed added more value to this compilations. Focused theme such as ethnobotanical trends and techniques, phytochemistry, biological activities, ethnopharmacology and clinical studies is adding and contributing a lots value to this book in discovering leads for medicine formulations.

      • Biochemistry
        October 2013

        Understanding and Exploiting Protein–Protein Interactions as Drug Targets

        by Giovanna Zinzalla

        Protein–protein interactions are one of most important classes of molecular targets in biotechnology. The ten chapters of this book provide an understanding of the key aspects in targeting PPIs with synthetic agents in a concise yet comprehensive manner. Experts in the field review the different strategies and chemical approaches that are used to target PPIs, discussing both established and novel methods. The in vitro tools used to assess the binding affinity and selectivity of PPI inhibitors are highlighted, and in silico tools used to aid the rational design of ligands are also reviewed. The book closes with a discussion of possible future directions to make this so-called ‘undruggable’ class of targets druggable. The book is a valuable source of information about targeting PPIs with synthetic agents, and provides a useful guide to the different chemical approaches that can be pursued and the in vitro analysis that can be used to assess potential PPI inhibitors.

      • Biochemistry
        July 2019

        Biochemistry and Human Nutrition

        by Manvesh Kumar Sihag

        The book will be helpful for those students, who study biochemistry and/or human nutrition as one of the subjects in Food Technology, Food Science and Technology, Food and Nutrition and other allied streams of under-graduate levels. This book is mainly divided into two sections: 1) Biochemistry; 2) Human Nutrition. First section comprises eight chapters based on metabolism of macronutrients (carbohydrates, proteins and lipids), basics of vitamins, enzymes, hormones and nucleic acids. Second section deals with the digestion & absorption of macronutrients, nutritional requirements of different age groups, analytical methods for qualitative & quantitative determination of nutrients, milk intolerance & hypersensitivity, safety aspects of food additives, toxic elements and radionuclides and various nutritional polices.

      • Physiology
        October 2011

        Physio-Biochemistry and Biotechnology of Vegetable Crops

        by M.K. Rana

        This book is aimed at providing systematic information on nutritional importance of vegetables in human nutrition, physiology, post-harvest technology, biochemistry and biotechnology of vegetables at a single source. The book contains very concise and precise information on physio-biochemical and biotechnological aspects of vegetable crops and also covers areas like resistance against diseases and herbicides and tolerance against drought and salinity and the physical aspects of quality, i.e., shape, size, texture, colour, tenderness, etc. It also contains the information on best possible solutions of problems faced by the students, scientists, growers and trade. The information given in this book is truly based on scientific records of scientists working on vegetables in various institutes. The book on physio-biochemical and biotechnological aspects of vegetable crops compiled for the students of postgraduate and postdoctoral programs is one such attempt to make them learn and understand the subject more precisely and motivate them o improve their knowledge in the field of physio-biochemistry and biotechnology of vegetables crops to meet the future needs. In addition, this book may be user-friendly to others who have the concern to expand their knowledge in the field of physio-biochemistry and biotechnology of vegetable crops and wish to fetch more remuneration from vegetable crops.

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